Abstract

Synthesis and Bio-Evaluation of Some New Phenyl Pyrazoline Derivatives from Pera-Chloro Benzaldehyde Moiety

SHAILESH.H. SHAH1, J. R. SHUKLA3 and PANKAJ S. PATEL2

1Department of Chemistry,
Patel JBR Arts, Patel AMR Commerce & Patel JDKD Science College,
Borsad, Gujarat, INDIA.
2Department of Chemistry,
Sheth LH Science College, Mansa, INDIA.
3Shri CNPF Arts, DN Science Collège, Dabhoi, INDIA

ABSTRACT

A New series of 4-(4-Chloro phenyl)-3-chloro-1-{4-[5- (Substituted phenyl)-1-phenyl- 4,5-dihydro-pyrazol-3-yl]phenyl} azetidin-2-one are synthesized by reacting 3-chloro-1-{4-[3- (Substituted phenyl)prop-2-enoyl]phenyl}-4-(4-Chloro phenyl) azetidin-2-one (0.01M) and phenyl hydrazine (0.01M) in presence of gl. Acetic acid. All these compounds were characterized by means of their IR, 1H NMR, Spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method.

Keywords :Chalcones, Phenyl Pyrazolines, azetidin-2-one, Antimicrobial activity.