Sodium toluene-4-sulfonate Catalyzed Microwave Assisted Efficient Synthesis and Antimicrobial Assay of Substituted 2-aryl benzoxazoles in Aqueous Medium

Sandip Patil1, Pushpendra Sharma1 and Santosh Kamble*2

1Department of Chemistry, Sri Satya Sai University of Technology and Medical Sciences, Sehore, Madhya Pradesh (M.P.), INDIA. 2Department Chemistry, Yashavantrao Chavan Institute of Science (Autonomous), Satara, Maharashtra, INDIA.


The 2- substituted benzoxazoles have been found to be excellent key motif which shows broad spectrum of biological activity because of this it has great interest for the development of newer methods of synthesis. We predicted that the use of sodium toluene-4-sulfonate as catalyst in aqueous medium for synthesis of 2- substituted benzoxazoles provides an alternative green pathway for these bioactive compounds. In the present work we report environmentally benign synthesis of benzoxazoles from 2-amino phenol and substituted aromatic carboxylic acids by using sodium toluene-4-sulfonate catalysis under microwave irradiation in aqueous medium and antimicrobial evaluation of synthesized benzoxazoles.

Keywords :sodium toluene-4-sulfonate, 2-aryl benzoxazoles, microwave, aqueous medium, antimicrobial assay.