Antibacterial Activity and Molecular Modeling of Ni(II)-, Cu(II)- and Mn(II)-Salophen Complexes

Md. Ali Asraf1*, Md. Faruk Hossen1, Rausan Zamir1 and Md. Kudrat-E-Zahan1

Department of Chemistry, Rajshahi University, Rajshahi-6205, BANGLADESH.


Nickel, copper and manganese complexes 1-3 were synthesized from the reaction of the salophen ligand, Slp with their respective acetate salts. All compounds were characterized with 1H and 13C NMR, FT-IR and ESI-MS spectroscopy. In addition, antibacterial activities of the ligand and its complexes were studied. The investigation of antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and carbapenem &colistin resistant Klebsiella pneumoniae showed all the complexes have remarkable antibacterial activity. The antibacterial effect of all the complexes against K. pneumoniae is of great interest as the bacterium, is resistant to two most important therapeutic options for treatment of multi-drug resistant Gram-negative bacteria, including polymyxins and carbapenems. The 3D molecular modeling of a representative complex was carried out on ChemDraw Ultra 12.0 software.

Keywords :Antibacterial Activity; Molecular Modeling; Ligand; Metal Complex.