Abstract

Microwave Assisted Synthesis, Characterization and Bioactivity Study of Binuclear Complexes of Schiff base derived from 2-Amino-5, 6-dimethyl benzimidazole and Terephthalaldehyde

M.G. Undegaonkar1*, S.P.Moharir2, V.N. Bhosale3 and S.R. Mirgane4

1Dept. of Chemistry, ASC College Badnapur, Dist.-Jalna-431202 (MS), INDIA. 2Dept. of Chemistry, Siddharth ASC College Jafrabad, Dist.-Jalna (MS), INDIA. 3Principal, Shivaji Arts, Commerce and Science College Kannad, Dist. - Aurangabad (MS), INDIA. 4Dept. of Chemistry, JES College Jalna, Dist.-Jalna (MS), INDIA.

ABSTRACT

Microwave assisted solvent free synthesis of a bidentate novel Schiff base ligand was performed by treating 2-Amino-5, 6-dimethyl benzimidazole and Terephthalaldehyde in 2:1 molar proportion. Final yield obtained after purification was high. This novel ligand was further treated with some transition metal salts such as Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ag(I) metal salts to give stable metal complex under solvent free condition in the same micro oven. Formation of both the novel ligand and its metal complexes was initially confirmed by their distinguishing color, exact melting points and TLC analysis. Novel Schiff base ligand was further characterized by elemental analysis, IR spectroscopy, LCMS and 1H NMR Spectroscopy. The band observed in IR spectra and peaks observed in 1H NMR supports predicted structure of ligand, also peaks observed in LCMS confirms ligand structure. The metal complexes were further representatively characterized by UV spectroscopy, IR spectroscopy and Differential Scanning Calorimetry (DSC). Both the novel ligand and its transition metal complexes were screened for antimicrobial activity against Escherichia Coli, Staphylococcus Aureus & Salmonella Typhi by MIC measurement.

Keywords :Microwave, solvent free, 2-Amino-5, 6-dimethyl benzimidazole, Terephthalaldehyde.