Abstract

Preparation, Spectroscopy Characterization and Anticancer Activity of New Polyhydroxy Ligand and its Metal Complexes

Abdou Saad El-Tabl*1, Moshira Mohamed Abd-El Wahed, Abeer Alaa Nabawy, Shaimaa Mohamed Faheem

1Department of Chemistry, Faculty of Science,
El-Menoufia University, Shebin El -Kom, EGYPT.
2Department of Pathology, Faculty of Medicine,
El-Menoufia University, Shebin El-Kom, EGYPT.

ABSTRACT

New binuclear Mn (II),Co (II),Ni (II),Cu (II),Zn(II),Cd (II), and Pb(II), of (1Z,2Z,5Z,6Z)-diethyl N'1,N'6-bis(2-hydroxyphenyl)-2,5-bis(1-((2-hydroxyphenyl) amino)ethylidene)hexanebis(imidate) dihydrate have been prepared and characterized using elemental and thermal analysis, IR,UV-VIS, 1H-NMR,mass spectroscopy, magnetism, conductivity and ESR measurements. The conductivity data indicate non electrolytic in nature. The elemental and spectral data confirmed distorted octahedral structure of the complexes. The ESR spectra show the complexes anisotropic and isotropic type with covalent bond character. The invitro cytotoxic activity of the ligand and some of its complexes have been studied against liver cancer carcinoma.

Keywords :Schiff-base, Complexes, Spectra, Magnetism, Thermal analyses, ESR, chemocytotoxic activity.