Abstract

A Prenylated Flavanone and Other Constituents of the Twigs of Millettia duchesnei (Leguminosae)

Peclar L. Bouobouo1, Hermia N. Ikome1, François Ngandeu2, Hanh Dufat3, Alembert T. Tchinda1 and Bonaventure T. Ngadjui4

1Institute of Medical Research and Medicinal Plants Studies (IMPM),
P.O. Box 13033 Yaounde, CAMEROON.
2Faculty of Agronomy and Environmental Sciences,
Evangelical University of Cameroon, P.O. Box 129 Bandjoun, CAMEROON.
3Laboratoire de Pharmacognosie U.M.R. au C.N.R.S. N° 8638,
Faculté des Sciences Pharmaceutiques et Biologiques,
Université René Descartes,
Paris 5, 4 avenue de l’ Observatoire 75270 Paris cedex-FRANCE
4Department of Organic Chemistry, Faculty of Science,
University of Yaounde I, P.O. Box 812,Yaounde, CAMEROON.

ABSTRACT

Chemical investigation of the twigs of MillettiaduchesneiDeWild (Leguminosae) led to the isolation of a new prenylated flavone, edikinone (1) together with seven known rotenoids:6a,12a-dehydrodeguelin, 6-methoxy-6a,12a-dehydrodeguelin, 6-hydroxy-6a,12a-dehydrodeguelin, 6-oxo-6a,12a-hydrodeguelin, elliptone, 12-deoxo- 12-methoxyelliptone, 12a-hydroxyelliptone, flavonoids:eriodictyol, catechin andmedicarpin, the two triterpenoids: lupeol and arjunolic acid and one steroid: stigmasterol. The structure of 3 as well as those of the known compounds were elucidated by using spectroscopic methods (1D and 2D NMR spectroscopy and MS analyses) and also by comparison with data from literature. Eriodictyol, catechin, medicarpin, lupeol, arjunolic acid and stigmasterol are reported for the first time from M. duchesnei.

Keywords :Millettiaduchesnei, Leguminosae, ekidinone, rotenoids, steroids.