Abstract

Preparation, Spectroscopic Characterization and Antitumor Activity of New Metal Complexes of Sodium 4,4'-((2E,2'E)-2,2'-((4,6-dihydroxy-1,3-phenylene)bis(ethan-1-yl-1-ylidene))bis(hydrazinecarbonyl)) diphenolate hydrate

Abdou S. El-Tabl*1, Moshira M. Abd-El Wahed2, Mohamed M. El-Basyouny1 and Shaimaa Mohamed Faheem1

1Department of Chemistry,
Faculty of Science, El-Menoufia University, Shebin El -Kom, EGYPT.
2Department of Pathology,
Faculty of Medicine, El-Menoufia University, Shebin El-Kom, EGYPT.

ABSTRACT

New Series of Cu(II), Co(II), Ni(II), Mn(II), Zn(II), Cd(II), Sr(II), Ag(I), and mixed Mn(II) / CU(II), Ni(II) / Pb(II), Mn(II) / Pb(II), Ni(II) / Zn(II) and Mn(II) / Zn(II) complexs have been prepared and characterized using analytical, physical and spectroscopic techniques, namely IR, Uv-vis.,1H-NMR and Mass spectra as well as Magnetism, Thermal analysis (DTA/TGA) and ESR measurements. Molar conductance values are relatively low, showing their non-electrolytic nature. The ESR spectral of the metal complexes shows anisotropic and isotropic type with covalent bond character. The cytotoxicity activity of the ligand and some of its complexes against hepatocellular carcinoma have been studied. The results show :- Cu(II)complex(3) >Cd/Ni(I) complex(6) >Cu complex (13) > standard drug (Sulfo-Rhodamine-B-stain (SRB)) > ligand (1) > Ag(II) complex(11) > Zn(II) complex(5). Complexes (3) and (6) are the most effective among the complexes and standard drug. Complexes (3) and (6) should be further investigated invivo in order to establish their potential to improve liver cancer treatment.

Keywords :Ligand, Complexes, Spectra, Magnetic moments, ESR, Chemotherapeutic effect against hepatocellular carcinoma.