Analytical and Pharmaceutical Formulation Analysis Based on Ion Selective Electrode Determination using Drug of Levamisole and its Application

Sabah M. Moltazem

Assistant Prof. of Analytical and Inorganic Chemistry, Faculty of Science, Besha University, KINGDAM OF SAUDIA ARABIA.


Ion-selective electrodes in this work is much simpler, more rapid and more economic than various other analytical methods. Four novel levamisole ion selective electrodes were fabricated, characterized and used for determination of levamisole in pharmaceutical formulations. The proposed sensors incorporated levamisole ammonium reineckate or levamisole potassium tetraiodomercurate ion pair complexes as electroactive materials in PVC matrix membrane and dioctylphthalate or o-nitrophenyloctyl ether as solvent mediators. The sensors exhibited fast and stable near Nernstian cationic response of 57±0.1 mV and 39 ± 0.5 mV/ concentration decade of levamisole in the concentration range of 1.0× 10-6 -1.0× 10-1 M, receptively. The lower limit of detection was 0.21± 0.7 ppm. It was found that sensor based on ammonium renickate as ionic counter and o-nitrophenyloctyl ether was the best and was used throughout this investigation in pH range.

Keywords :Ion-selective electrodes, levamisole potassium tetraiodomercurate, o-nitrophenyloctyl.