Cytotoxic Evaluation of (E)-1-(2',4'-difluorobiphenyl-4-yl)-3-arylprop-2-en-1-one Derivatives

M. Fathimunnisa1 and H. Manikandan2

1Department of Chemistry, AVC College (autonomous), Mannampandal - 609 305, Tamilnadu, INDIA.
2Department of Chemistry, Annamalai University, Annamalainagar - 608 002, Tamilnadu, INDIA.


A series of (E)-1-(2',4'-difluorobiphenyl-4-yl)-3-arylprop-2-en-1-one derivatives were synthesized and in vitro cytotoxic activity of the compounds were evaluated against Hep-2 cell line by MTT assay. The structure activity relationship based on the type of substituent on C-3 propenones was explored.

Keywords :Cytotoxic activity; MTT assay; Hep-2 cell line; Difluorobiphenyl chalcone.